U-substitution is exactly the way to go.
First off, you have:
^5 dx)
Now, let

, so that

. Then

.
Put this all back into the original integral, factoring out the -1/3 since it's a constant. This leaves you with:

Integrating that with respect to u gives you this (don't forget to multiply through by the -1/3):

Now replace the u with 6 - 3x, giving you a final answer of:
^6 + C)
That's all.